Abstract            Volume:4  Issue-5  Year-2016         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

The purpose of this study to evaluate the seed extract (aqueous) on the mice liver lesions that caused by ethanol. Twenty albino mice were randomly assigned to five groups A, B, C, D and E. (each group consist 4 mice), the first group was control group administrated only normal diet and water, the second group administrated with ethanol for fifteen days, the third group administrated with ethanol for twenty one days, the fourth group administrated with ethanol for fifteen days and treated with seeds extract for 10 days, the fifth group administrated with ethanol for twenty one days and treated with seeds extract for 10 days. The GOT and GPT levels were increased and showed high significant changes (P < 0.01) in groups that administrated ethanol only compared with control group and also the liver tissue showed different lesion including necrosis, degeneration, infiltration, but when these groups treated with seed extract, the GOT and GPT levels return to the normal ranges and the liver tissue became normal and repaired completely. It was concluded from this study that aqueous extract of Fenugreek has amply good effect on the weight on liver enzymes and tissue.

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