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Abstract                 Volume:4  Issue-5  Year-2016          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcret@gmail.com

Study the Physiological and Histological Changes that Induced by Ethanol in Mice Liver and the Role of Trigonella foenum - graecum Seeds Extract to Treatment
Zahra B.Mohammed1 and Zainab A. Hassan2*
1Dept of biology, College of Science, University of Kirkuk, Iraq
2Department of Pathological analysis, Technical Institute/Hawija, Kirkuk, Iraq
*Corresponding author
Abstract:

The purpose of this study to evaluate the seed extract (aqueous) on the mice liver lesions that caused by ethanol. Twenty albino mice were randomly assigned to five groups A, B, C, D and E. (each group consist 4 mice), the first group was control group administrated only normal diet and water, the second group administrated with ethanol for fifteen days, the third group administrated with ethanol for twenty one days, the fourth group administrated with ethanol for fifteen days and treated with seeds extract for 10 days, the fifth group administrated with ethanol for twenty one days and treated with seeds extract for 10 days. The GOT and GPT levels were increased and showed high significant changes (P < 0.01) in groups that administrated ethanol only compared with control group and also the liver tissue showed different lesion including necrosis, degeneration, infiltration, but when these groups treated with seed extract, the GOT and GPT levels return to the normal ranges and the liver tissue became normal and repaired completely. It was concluded from this study that aqueous extract of Fenugreek has amply good effect on the weight on liver enzymes and tissue.

Keywords: Ethanol in mice liver, Trigonella foenum – graecum, seeds extract.
 
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How to cite this article:

Zahra B.Mohammed and Zainab A. Hassan. 2016. Study the Physiological and Histological Changes that Induced by Ethanol in Mice Liver and the Role of Trigonella foenum - graecum Seeds Extract to TreatmentInt.J.Curr.Res.Aca.Rev. 4(5): 12-20
doi: http://dx.doi.org/10.20546/ijcrar.2016.405.002