Abstract            Volume:13  Issue-8  Year-2025         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

Malaria remains a major public health problem in the intertropical zone. Due to the growing problem of Plasmodium's resistance to conventional antimalarials, which is largely responsible for the appearance of severe forms of the disease, there is an urgent need to discover new molecules. Most of these drugs are synthesized from plants or modelled on the structures of their compounds. Gymnanthenum amygdalinum (Asteraceae) have been reported to have antimalarial effects in traditional medicine. The objective of this work was to investigate the antiplasmodial and preventive activities of G. amygdalinum on Plasmodium berghei-induced cerebral malaria in mice. Mice were infested intraperitoneally with 200 μl of blood containing 10⁷ infected red blood cells with delicate monitoring of signs of cerebral malaria. On the sixth day post-infestation, the different treatments extracts from the barks of G. amygdalinum were administered to the various groups of mice except the control mice. The results showed that G. amygdalinum had antiplasmodial and preventive properties on chronic P. berghei infection. All doses of G. amygdalinum showed significant suppressive activity (P < 0.001) compared with negative control. Mortality rates obtained two days after treatment were 77.56, 58.18, 53.46 and 38.22% respectively at doses 187, 93.50, 46.75 and 18.7 mg/Kg.

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