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Abstract                 Volume:4  Issue-7  Year-2016          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Antioxidant Activity of Lactococcus lactis and Curcumin Inhibits Lifespan Shorten and Oxidative Stress in Drosophila melanogaster
SoJung Park1, WooSung Jeong2, KyungGon Kim3, Dae-Jung Kang4, Sang Yun Kim5 and Sang-Tae Kim6*
1Hankuk Academy of Foreign Studies, 50-Eydaero 54 Bungil Mohyenmaen Meongincity Keeonggeedo, 17035 Korea 2Whimoon High School, Yeoksamro 541, Kangnamgu 06183, Korea 3Asan Institute for Life Sciences, Asan Medical Center, Seoul, Department of Medicine, University of Ulsan College of Medicine, 43 gil Olympic-ro, Pungnapdong, Songpagu, Seoul 138-736, Republic of Korea 4Ildong Pharmaceutical Co. Ltd. 20 Samsung 1-ro, 1-gil, Hwaseong-si, Gyeonggi-do 18449, Korea 5Department of Neurology, Seoul National University College of Medicine, Goomi-ro, Bundanggu Seongnam city, Geonggeedo, 647-707 Republic of Korea 6W7, Biomedical Research Institute, Department of Neurology, Seoul National University College of Medicine, Healthcare Innovation Park3F, Goomi-ro, Bundanggu Seongnam city, Geonggeedo, 647-707 Republic of Korea
*Corresponding author
Abstract:

Oxidative stress has been strongly correlated with Alzheimer disease (AD) pathogenesis and the formation of intracellular Aβ42has been reported in AD Drosophila model. In this study, the effect of curcumin and Lactococcus lactis was studied on lifespan, flight ability and oxidative stress in the AD Drosophila model flies and oxidative stress and protein carbonyl content were investigated in the fly brains. The progeny (AD flies) expressing human Aβ42was exposed to 25, 50, and 100 µM of curcumin or 2x105, 2x106 and 2x107 of LAL in the diet for 7 days. The result showed that the treatment of flies to curcumin and LAL induced a dose dependent significant delay of life-span, reduction in the oxidative stress and increase in the flight ability of AD Drosophila model. As a result, we concluded that curcumin and LAL can be potent in reducing AD symptoms.

Keywords: Oxidative stress; Alzheimer disease; life-span; flight ability; Lactococcus lactis
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How to cite this article:

SoJung Park, WooSung Jeong, KyungGon Kim, Dae-Jung Kang, Sang Yun Kim and Sang-Tae Kim. 2016. Antioxidant Activity of Lactococcus lactis and Curcumin Inhibits Lifespan Shorten and Oxidative Stress in Drosophila melanogaster.Int.J.Curr.Res.Aca.Rev. 4(7): 152-164
doi: http://dx.doi.org/10.20546/ijcrar.2016.407.019