Abstract Volume:4 Issue-7 Year-2016 Original Research Articles
|Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Oxidative stress has been strongly correlated with Alzheimer disease (AD) pathogenesis and the formation of intracellular Aβ42has been reported in AD Drosophila model. In this study, the effect of curcumin and Lactococcus lactis was studied on lifespan, flight ability and oxidative stress in the AD Drosophila model flies and oxidative stress and protein carbonyl content were investigated in the fly brains. The progeny (AD flies) expressing human Aβ42was exposed to 25, 50, and 100 µM of curcumin or 2x105, 2x106 and 2x107 of LAL in the diet for 7 days. The result showed that the treatment of flies to curcumin and LAL induced a dose dependent significant delay of life-span, reduction in the oxidative stress and increase in the flight ability of AD Drosophila model. As a result, we concluded that curcumin and LAL can be potent in reducing AD symptoms.
How to cite this article:SoJung Park, WooSung Jeong, KyungGon Kim, Dae-Jung Kang, Sang Yun Kim and Sang-Tae Kim. 2016. Antioxidant Activity of Lactococcus lactis and Curcumin Inhibits Lifespan Shorten and Oxidative Stress in Drosophila melanogaster.Int.J.Curr.Res.Aca.Rev. 4(7): 152-164