Abstract            Volume:4  Issue-8  Year-2016         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

Aegle marmelos (linn) Correa commonly known as Bael (or Bel) belonging to the family rutaceae, is a moderatesized, slender and aromatic tree and  traditionally used for curing different aliments. Hence the present investigation is carried out to determine the possible chemical components from Aegle marmelos leaves by GC-MS Technique. This analysis reveales that the  ethanolic extract  of Aegle marmelos leaves contains around eleven compounds where trioxsalen, pentadecanoic acid,13-methyl-,methyl ester, propanedioic acid,(4-oxo-2-cyclopenten-1-lyl)-,dimethyl ester, eugenol, Pentadecane 2,4-dione has antiulcer activity.A number of chemical constituents and various therapeutic effects of A. marmelos have been reported by different workers. Helicobacter pylori (H. pylori) successfully resides in the human stomach in highly acidic conditions, causing a variety of gastroduodenal lesions, including peptic ulcer. For acid acclimation of H. pylori, two types of enzymes, urease and carbonic anhydrase (CA), play a central role. High secretion of carbonic anhydrases leads to the formation of peptic ulcer disease. The emergence of Bioinformatics has provided a platform to explore diseases at the molecular level using Computational techniques. The objective of present study is to perform docking analysis against carbonic anhydrases involves in causing peptic ulcer using Autudock 4.2 software.

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