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Abstract                 Volume:4  Issue-8  Year-2016          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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GCMS and in Silico Docking Analysis of Aegle marmelos for its Anti-ulcer Activity against Carbonic Anhydrase
Moogambigai1, M. Victoriya Salomi1,2 and R. Padmini1,2
1Department of Biochemistry and Bioinformatics, Dr. MGR Janaki College of Arts and Science for Women, Chennai, Tamil Nadu, India
2Research Scholar, Department of Biotechnology, Mother Teresa Women’s University, Kodaikanal, Tamil Nadu, India
*Corresponding author
Abstract:

Aegle marmelos (linn) Correa commonly known as Bael (or Bel) belonging to the family rutaceae, is a moderatesized, slender and aromatic tree and  traditionally used for curing different aliments. Hence the present investigation is carried out to determine the possible chemical components from Aegle marmelos leaves by GC-MS Technique. This analysis reveales that the  ethanolic extract  of Aegle marmelos leaves contains around eleven compounds where trioxsalen, pentadecanoic acid,13-methyl-,methyl ester, propanedioic acid,(4-oxo-2-cyclopenten-1-lyl)-,dimethyl ester, eugenol, Pentadecane 2,4-dione has antiulcer activity.A number of chemical constituents and various therapeutic effects of A. marmelos have been reported by different workers. Helicobacter pylori (H. pylori) successfully resides in the human stomach in highly acidic conditions, causing a variety of gastroduodenal lesions, including peptic ulcer. For acid acclimation of H. pylori, two types of enzymes, urease and carbonic anhydrase (CA), play a central role. High secretion of carbonic anhydrases leads to the formation of peptic ulcer disease. The emergence of Bioinformatics has provided a platform to explore diseases at the molecular level using Computational techniques. The objective of present study is to perform docking analysis against carbonic anhydrases involves in causing peptic ulcer using Autudock 4.2 software.

Keywords: Aegle marmelos,GC-MS analysis, Antiulcer activity.
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How to cite this article:

Moogambigai, S., M. Victoriya Salomi and Padmini, R. 2016. GCMS and in Silico Docking Analysis of Aegle marmelos for its Anti-ulcer Activity against Carbonic Anhydrase.Int.J.Curr.Res.Aca.Rev. 4(8): 73-97
doi: http://dx.doi.org/10.20546/ijcrar.2016.408.007