Abstract            Volume:4  Issue-8  Year-2016         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

Paracetamol is a non-opioid analgesic that causes analgesia by serotonergic mechanism of action and inhibiting prostaglandin synthesis in the central nervous system. The usual dose of Paracetamol is 1g every 6 hours; however, this dosage does not afford enough postoperative analgesia. This study compared the effectiveness of 2g Paracetamol to usual 1g dosage in controlling gynecologic laparoscopic surgical pain. In this double blind randomized clinical trial, 30 patients aged 20-70 years with ASA class I or II of laparoscopic gynecologic surgery were studied. At the end of surgery, the study group (15 cases), received 2 grams of Paracetamol and the control group (15 cases) received 1g Paracetamol in 100ml normal saline solution within 15 minutes. The prevalence of abdominal pain and shoulder pain in recovery in study group were 4.34% and 00% in the control group was 47.82% and 4.34%, respectively (P<0.001 and P =0.013). The mean abdominal pain score in recovery in study group (0.07 ± 0.33) was significantly lower than in control group (2.01±1.62) (pË‚0.001). The mean shoulder pain score in recovery in study group (0.00 ± 0.00) was significantly lower than in control group (1.53±0.55) (pË‚0.018). Time to request for the first analgesic in the study group was longer (P=0.03). Liver tests in the 24 hours after surgery in both groups were not significantly different (p˃0.05). Prescription of Paracetamol 2g at the end of surgery, compared with 1gr dosage, can safely and effectively reduce the prevalence and scores of acute postoperative pain after gynecologic laparoscopic surgery.

Download this article as