Abstract            Volume:4  Issue-10  Year-2016         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

The present study include two parts: part one was aimed to characterize the extracted flavonoids from cabbage (Brassica olearacea Var-Capitata) and part two include studying the effect of extracted flavonoids on some biochemical parameters in alloxan-induced diabetic female rats.  High performance liquid chromatography (HPLC) was employed to identify and quantify the five important flavonoids components (Gallic acid, Catechin, Epicatechin, Epicatechin-3-O- gallate and Anthocyanins). The concentration of Gallic acid (34.776 µg/ml), Catechin (122.739 µg/ml), Epicatechin (110.434 µg/ml), Epicatechin-3-O- gallate (30.07 µg/ml ) and Anthocyanins (27.532 µg/ml) were detected in the extract from cabbage. Fifteen female albino rats equally divided into three experimental groups were used. Two groups served as normal and diabetic control and the third group received (40mg/Kg) flavonoid treatment. Oral administration of plant extracts on alloxan induced diabetic rats showed a marked significant increase(P < 0.05)  in the levels of biochemical parameters such as blood glucose, triglycerides, cholesterol, LDL cholesterol, VLDL cholesterol and GOT & GPT activity, whereas significant decrease (P < 0.05) in the level of HDL. Finally the results showed that treatment with flavonoid extract significantly reduced the blood glucose, triglycerides, cholesterol, LDL cholesterol, VLDL cholesterol and GOT & GPT activity, there were significant increase in the level of HDL compared to diabetic control.

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