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Abstract                 Volume:4  Issue-10  Year-2016          Original Research Articles


Online ISSN : 2347 - 3215
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Characterization of Extracted Flavonoids from Cabbage and Study its Biochemical Effect on Alloxan- Induced Diabetic Female Rats
Yasmin Hameed Jasim1, Meena Abd-Alsalam Mustafa1, Amjad Abbawy2 and Israa Zainal2*
1Samara University, College of Applied Science, Chemistry Department, Iraq
2Kirkuk University, College of Education And Pure Science, Chemistry Department, Iraq
*Corresponding author
Abstract:

The present study include two parts: part one was aimed to characterize the extracted flavonoids from cabbage (Brassica olearacea Var-Capitata) and part two include studying the effect of extracted flavonoids on some biochemical parameters in alloxan-induced diabetic female rats.  High performance liquid chromatography (HPLC) was employed to identify and quantify the five important flavonoids components (Gallic acid, Catechin, Epicatechin, Epicatechin-3-O- gallate and Anthocyanins). The concentration of Gallic acid (34.776 µg/ml), Catechin (122.739 µg/ml), Epicatechin (110.434 µg/ml), Epicatechin-3-O- gallate (30.07 µg/ml ) and Anthocyanins (27.532 µg/ml) were detected in the extract from cabbage. Fifteen female albino rats equally divided into three experimental groups were used. Two groups served as normal and diabetic control and the third group received (40mg/Kg) flavonoid treatment. Oral administration of plant extracts on alloxan induced diabetic rats showed a marked significant increase(P < 0.05)  in the levels of biochemical parameters such as blood glucose, triglycerides, cholesterol, LDL cholesterol, VLDL cholesterol and GOT & GPT activity, whereas significant decrease (P < 0.05) in the level of HDL. Finally the results showed that treatment with flavonoid extract significantly reduced the blood glucose, triglycerides, cholesterol, LDL cholesterol, VLDL cholesterol and GOT & GPT activity, there were significant increase in the level of HDL compared to diabetic control.

Keywords: Brassica oleracea L. var. capitata, flavonoids,HPLC,diabetic rats,lipid profile,GOT & GPT activity.
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How to cite this article:

Yasmin Hameed Jasim, Meena Abd-Alsalam Mustafa, Amjad Abbawy and Israa Zainal. 2016. Characterization of Extracted Flavonoids from Cabbage and Study its Biochemical Effect on Alloxan- Induced Diabetic Female Rats.Int.J.Curr.Res.Aca.Rev. 4(10): 84-94
doi: http://dx.doi.org/10.20546/ijcrar.2016.410.010