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Abstract                 Volume:4  Issue-11  Year-2016          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Protective Effects of Gramine on Cell Surface Integrity and Status of Lipid Profile during DMBA induced Oral Carcinogenesis
Ramu Arun Kumar, Kathiresan Suresh*, Ramadoss Hemavardhini and Nallu Anandhi
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar- 608002, Tamilnadu, India
*Corresponding author
Abstract:

Gramine is a pungent alkaloid significantly found in barley (Hordeum vulgare), that have antioxidant and chemopreventive properties owing their indoles nature. The present study aimed to examine the protective effect of gramine on cell surface glycoconjugates and lipid profile status against 7,12-dimethylbenz[a]anthracene (DMBA) induced  hamster  buccal pouch carcinogenesis.  Oral squamous cell carcinoma was induced in male Syrian golden hamster’s buccal pouch by painting with 0.5% DMBA in liquid paraffin at three times a week of 16 weeks. We observed malignancy with marked abnormalities of glycoconjugates (protein bound hexose, hexosamine, sialic acid and fucose), lipid (Total cholesterol, Phospholipids, Free fatty acid and C/P ratio) status in tumor bearing hamsters. Oral administration of gramine (80 mg/kg b.wt), to DMBA painted cancer animals significantly modulate the levels of cell surface glycoconjugates and lipid profiles activity to near normal range. Present study suggested that gramine has potent chemopreventive efficacy on protected the abnormalities on cell surface glycoconjugates and lipid status against oral cancer.

Keywords: Oral cancer,DMBA,Alkaloid, Glycoconjugates, Lipid Profile.
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How to cite this article:

Ramu Arun Kumar, Kathiresan Suresh, Ramadoss Hemavardhini and Nallu Anandhi. 2016. Protective Effects of Gramine on Cell Surface Integrity and Status of Lipid Profile during DMBA induced Oral Carcinogenesis.Int.J.Curr.Res.Aca.Rev. 4(11): 8-17
doi: http://dx.doi.org/10.20546/ijcrar.2016.411.002