Abstract            Volume:4  Issue-11  Year-2016         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

DNJ was studied for its efficacy in glycogenesis metabolism. Streptozotocin (STZ) is known to induce diabetes. Mice were exposed to different doses (40mg/kg.bw and 60mg/kg.bw) and periods of 30 days of STZ and DNJ. Exposure to STZ resulted in the increase in the blood glucose levels with the corresponding decrease in liver glycogen and increase in glycogen phosphorylase and glucose-6-phosphatase activities indicating an acceleration of glycogenolysis in liver and decreased peripheral utilization of glucose. Mice treated with the combination of STZ and DNJ showed again hyperglycemia which was less in degree when compared to hyperglycemia observed in animals treated only with STZ. However, the hyperglycemia in lower dose of STZ with DNJ was insignificant especially at 30 days of exposure. It is concluded that.DNJ at a dose of 60 mg/Kg/b.w. exhibited anti-hyperglycemic activity at longer period of exposure in mice. The anti-hyperglycemic activity could be attributed to the expression of insulin gene with associated changes in glycogen metabolizing enzymes.

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