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Abstract                 Volume:4  Issue-11  Year-2016          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Comparison of Serum Parathyroid Hormone (PTH) Levels in Hemodialysis and Peritoneal Dialysis Patients
Seyed Seifollah Beladi Mousavi1, Arman Shahriari2 and Fatemeh Roumi3*
1Department of Nephrology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2Research Center for Infectious Diseases of Digestive System, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran 3Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding author
Abstract:

Increase in serum PTH levels is one of the earliest disorders in mineral metabolism in patients with CKD. Since in a number of studies, high PTH levels have been significantly associated with better life expectancy in hemodialysis and peritoneal dialysis patients (114 and 117 and 133); therefore, due to the high prevalence of mineral metabolism and renal osteodystrophy in dialysis patients and the importance of parathyroid hormone in calcium and phosphate homeostasis, in this study PTH levels in hemodialysis and peritoneal dialysis patients were compared. In this cross-sectional study conducted in Ahvaz Imam Khomeini Hospital, 68 patients undergoing peritoneal dialysis and hemodialysis in the time period between March2014andFebruary2015 were selected by using convenience sampling‎method. Patients were studied in terms of age, gender, body mass index (BMI), calcium, phosphorus, alkaline phosphatase, Parathyroid hormone (PTH), number of dialysis and dialysis duration. Data were analyzed using SPSS software. In hemodialysis group, serum calcium level, phosphates level, alkaline phosphatase level and PTH level were 8.10 ± 8.40, 5.21± 4.90,‏390.00±574.61 and 233.00±330.89, respectively. Also, in peritoneal dialysis group, serum calcium level, phosphates level, alkaline phosphatase level and PTH level were8.50±8.59, 4.92±4.90, 374.00±251.00 and 363.76±313.50, respectively. There is a significant difference regarding calcium levels between patients on hemodialysis and peritoneal dialysis (P = 0. 001).Based on age, gender and underlying disease of diabetes, there is no significant difference regarding PTH levels between patients on hemodialysis and peritoneal dialysis (P> 0.05). In this study, it was observed that factors measured in hemodialysis and peritoneal dialysis patients, particularly PTH change with in Iranian society with low correlation and this finding could possibly be due to different genetic ora history of different underlying diseases. In this study, only calcium levels are significantly different in hemodialysis and peritoneal dialysis patients and it is suggested to put more emphasis on this variable in future studies. Moreover, it is suggested to increase information on changes in PTH levels followed by chronic kidney disease, through designing further studies and conducting longer follow-ups and evaluation of morbidities and mortalities in patients.

Keywords: Chronic kidney disease, peritoneal dialysis, hemodialysis, PTH
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How to cite this article:

Seyed Seifollah Beladi Mousavi, Arman Shahriari and Fatemeh Roumi. 2016. Comparison of Serum Parathyroid Hormone (PTH) Levels in Hemodialysis and Peritoneal Dialysis Patients.Int.J.Curr.Res.Aca.Rev. 4(11): 166-174
doi: http://dx.doi.org/10.20546/ijcrar.2016.411.021