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Abstract                 Volume:5  Issue-4  Year-2017          Original Research Articles

Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcret@gmail.com

Effect of Miltefosine on Growth and Metabolism of Leishmania donovani and Leishmania tropica Promastigotes
Husain F. Hassan* and Marowa E. Abdulla
Department of Biology, College of Science, University of Kirkuk, Iraq
*Corresponding author

Miltefosine was found to be potent inhibitor of Leishmania donovani and Leishmania tropica promastigotes growth in vitro. Miltefosine was found to be equally effective against both parasites with ED50> 0.0001 mg/ml. The results demonstrated that the effect of miltefosine may be attributed to the inhibition of the enzyme diethylacetonephosphate acetyltransferase, that lead to the damaging membrane phospholipid biosynthesis, thus causing cellular death. The results suggest that miltefosine might be a promising potential as antileishmanial drug.

Keywords: Leishmania, Promastigotes, Metabolism, Miltefosine.
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How to cite this article:

Husain F. Hassan and Marowa E. Abdulla. 2017. Effect of miltefosine on growth and metabolism of Leishmania donovani and Leishmania tropica promastigotes.Int.J.Curr.Res.Aca.Rev. 5(4): 95-101
doi: https://doi.org/10.20546/ijcrar.2017.504.014