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Abstract                 Volume:4  Issue-2  Year-2016          Original Research Articles

Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcret@gmail.com

Over expressed miRNA-31 is the Most Consistent and Unique Micro RNA in Ulcerative Colitis
Yifei Cao1, Chengtan Li1, Wen Li2, Yani Chen1, WeibinCai1, XiaohuaTan1, Liangwen Xu1, Lei Yang1 and Yutao Yan1*
116 Xuelin St.  School of Medicine, Hangzhou Normal University, Hangzhou 310036, Zhejiang, China
22 Ravinia Drive, Suite 1750, IHRC inc. Atlanta, Georgia, 30346, USA
*Corresponding author

Recently, several micro RNA (miRNA) profiling studies have been performed on ulcerative colitis (UC) tissues but with extremely inconsistency, their diagnostic or therapeutic value remains debate. Thus, this study aims to systematically evaluate the consistency of miRNAs from multiple independent studies. Eligible studies were collected from online programs, followed by a systematic analysis on miRNAs. Real time PCRs were employed to validate miRNA candidates. The target genes of high consistent miRNAs were collected with online programs. Enrichment analyses for gene ontology (GO) terms and Kyoto encyclopedia of genes and genomes (KEGG) pathways were carried out. A total of 272differentially expressed miRNAs were reported in 10 profiling studies, of which 166 were upregulated and 106 were down regulated. In the group of consistently up-regulated miRNAs (cutoff>4 times), miRNA-31 was the only miRNA found in 5 different studies. Among the 106 down-regulated miRNAs, none of them expressed consistently in more than 4 different studies. The increased miRNA-31 was confirmed by real-time PCR. Enrichment analyses demonstrated that the regulation of transcription and metabolic process play important roles during the interplay of miRNAs with UC. Conclusion: This systematic study demonstrates that pro-inflammatory miRNA-31 is the only consistently differently expressed miRNA.

Keywords: Ulcerative colitis, miRNA,Systematic study,Differential expression
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How to cite this article:

Yifei Cao, Chengtan Li, Wen Li, Yani Chen, WeibinCai, XiaohuaTan, Liangwen Xu, Lei Yang and Yutao Yan. 2016. Over expressed miRNA-31 is the Most Consistent and Unique Micro RNA in Ulcerative Colitis.Int.J.Curr.Res.Aca.Rev. 4(2): 147-159
doi: http://dx.doi.org/10.20546/ijcrar.2016.402.018