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Abstract                 Volume:5  Issue-6  Year-2017          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Menthol Ameliorates Secretagogue-Induced Gastric Acid Secretion in the Rat
Onwuchekwa Chinedu and K.G. Ibrahim
Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto Nigeria
*Corresponding author
Abstract:

Gastric ulcer, diarrhoea, irritable bowel syndrome (IBS) and constipation are some of the prevalent gastrointestinal diseases in global health problems today. The present work aimed to evaluate the gastric acid secretion effects of (-)-Menthol (ME). Male Wistar rats (n=6) weighing 200-230 g were used in all bioassays. Rats were orally treated with menthol (20, 40 and 60 mg/kg). After one hour, the rats were anaesthetized, cannulated and infused with either pentagastrin, carbachol or histamine. Gastric acid secretion (GAS) was assessed by continuous perfusion and its acidity determined by titration. Data were express as Mean± SEM. Student’s t-test and one-way ANOVA were used to determine levels of significance (p<0.05) with the aid of Graphpad Prism 5. There were significant decreases in pH over time (min) in all the menthol treated groups with the pentagastrin, carbacol and histamine stimulated GAS (mEq/l) compared to the basal normal saline groups.

Keywords: Menthol, gastric acid, gastric ulcer, titration.
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How to cite this article:

Onwuchekwa Chinedu and K.G. Ibrahim. 2017. Menthol Ameliorates Secretagogue-Induced Gastric Acid Secretion in the Rat.Int.J.Curr.Res.Aca.Rev. 5(6): 113-118
doi: https://doi.org/10.20546/ijcrar.2017.506.016