IJCRAR is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCRAR Articles.

INDEXED IN INDEX COPERNICUS - ICI Journals Master List 2016 - IJCRAR--ICV 2016: 81.15 For more details click here

Abstract                 Volume:5  Issue-7  Year-2017          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcret@gmail.com

Zinc Supplementation Significantly Improves Neurophysiological and Glycemic Measures in Patients with Diabetic Neuropathy
Sumana Gupta1*, Indira Maisnam2, Tapobrata Guharay3, Sandip Ghosh4, Apurba Kumar Mukherjee5 and Anil Baran Singha Mahapatra1
1Department of Physiology, R. G. Kar Medical College, Kolkata, West Bengal, India
2Department of Endocrinology, R. G. Kar Medical College, Kolkata, West Bengal, India
3Department of Community Medicine, R. G. Kar Medical College, Kolkata, West Bengal, India
4Department of Cardiology, R. G. Kar Medical College, Kolkata, West Bengal, India
5Department of General Medicine, R. G. Kar Medical College, Kolkata, West Bengal, India
*Corresponding author
Abstract:

Though tight glycemic control remains the cornerstone for prevention and management of Diabetic Neuropathy (DN), it is often inadequate. Zinc supplementation may offer symptomatic and functional improvement in these patients. We tried to evaluate the effects of zinc supplementation on Nerve Conduction Study (NCS) parameters and glycosylated hemoglobin (HbA1c) level in patients with DN and search for whether duration of diabetes affect outcome. Patients of type 2 diabetes mellitus (T2DM) with peripheral neuropathy, presenting at Diabetes clinic were enrolled for baseline and follow-up (after 12 weeks) evaluation of NCS parameters along with HbA1c for Cases (received zinc therapy100mg/day) and Controls (did not receive zinc). Cases divided into three groups according to diabetes duration and evaluated for any significant differences in the response to the zinc, reflected by NCS parameters and HbA1c.The observational follow-up study on 45 patients showed highly significant (p<0.01) improvement for Median and Tibial motor amplitude, Median sensory (amplitude, velocity) and Sural (latency, amplitude) after 12 weeks of zinc supplementation in Cases. Significant difference (p<0.05) in changes was seen among Cases (n=25) compared to Controls (n=20) in amplitude and velocity (motor parameters) and latency, amplitude, velocity (sensory parameters) along with HbA1c. Median motor latency and HbA1c level, after zinc therapy varied significantly in individuals with longest diabetes duration.

Keywords: Nerve Conduction Study, Diabetic Neuropathy, Zinc, HbA1c
Download this article as Download

How to cite this article:

Sumana Gupta, Indira Maisnam, Tapobrata Guharay, Sandip Ghosh, Apurba Kumar Mukherjee and Anil Baran Singha Mahapatra. 2017. Zinc Supplementation Significantly Improves Neurophysiological and Glycemic Measures in Patients with Diabetic Neuropathy.Int.J.Curr.Res.Aca.Rev. 5(7): 61-69
doi: https://doi.org/10.20546/ijcrar.2017.507.009