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International Journal of Current Research and Academic Review-e-iSSN - 2347 - 3215

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Abstract                 Volume:5  Issue-12  Year-2017          Original Research Articles

Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcret@gmail.com

Elastin Structure Protein Non-Enzymatic Glycation Inhibition Studies by Use of Secondary Metabolites of Withania somnifera
Mohammad Nadeem Khan*
SOS in Biotechnology, Bastar University, Jagdalpur (C.G.) 494001, India
*Corresponding author

NEGs (non-enzymatic glycation) accumulations particularly high in E.C.M., proteins are result in intra and inter molecular cross-linking and later has been hypotized to stiffening of these proteins and believed to play an important role in etiology of various NEGs related diseases (Basta et al., 2004). The goal of this research asses the energy level of W. somnifera (Withaferin –A) in Elastin (hydrophobic) structural protein interaction that made glycation adducts with glucose. The results level of binding energy of proteins and phyto constituents are high in Elastin (-8.4). The glucose and protein binding energy Elastin (-3.9). The energy level of Elastin high that’s clear indication that withaferin–A give best result of inhibitions was compared with glucose and protein binding energy. This preliminary finding gives an open window towards structure based drug design to finding noval inhibitory molecule of entities.

Keywords: Non-enzymatic glycation,Docking,Binding energy,Half-life,In-silico
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How to cite this article:

Mohammad Nadeem Khan. 2017. Elastin Structure Protein Non-Enzymatic Glycation Inhibition Studies by Use of Secondary Metabolites of Withania somnifera.Int.J.Curr.Res.Aca.Rev. 5(12): 25-39
doi: https://doi.org/10.20546/ijcrar.2017.512.005