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Abstract                 Volume:6  Issue-3  Year-2018          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcret@gmail.com

Prognostic Markers of Sepsis: Procalctionin vs C - Reactive Protein
Swati Sharma1*, Beena Uppal1 and Anuj Sud2
1Department of Microbiology, Maulana Azad Medical College, New Delhi-110002, India
2Department of Microbiology, Lok Nayak Hospital and Maulana Azad Medical College, New Delhi-110002, India
 
*Corresponding author
Abstract:

The utility of procalcitonin as a diagnostic marker of sepsis has been studied widely. However, there is limited literature on the role of procalcitonin as a prognostic marker in sepsis. The aim of this study was to assess the utility of procalcitonin in predicting mortality in patients of sepsis and to compare it with C-reactive protein. A total of 250 children aged 2 months to 5 years and clinically suspected of sepsis admitted in the paediatric emergency ward of a tertiary care hospital in North India were enrolled in the study. Blood sample was collected at the of admission for performing blood culture by conventional method and for estimation of serum procalcitonin and C-reactive protein by a fluorescence based immunoassay. Each patient was followed for a period of 30 days. Procalcitonin was found to be a better predictor of mortality than C-reactive protein in patients of sepsis. There was a significant difference in mean PCT value in patients who died during hospital stay and those who survived (p<0.0001). Patients who expired had mean PCT value 15 times that of patients who survived (mean= 72.78 ng/ml vs 5.43 ng/ml in survivors). The mean CRP level was higher in patients who died during hospital stay (mean= 68.22 mg/l vs 3.37 mg/l in survivors) but the difference was not statistically significant (p=0.018). Hence, the study showed that CRP is not a good predictor of mortality in children with sepsis. A high level of procalctionin in patients of sepsis at the time of admission is a predictor of high risk of mortality and hence must be taken as a warning sign to provide necessary treatment to the patient.

Keywords: Biomarkers,C-reactive protein,Procalcitonin,Pediatric sepsis,Sepsis mortality
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How to cite this article:

Swati Sharma, Beena Uppal and Anuj Sud. 2018. Prognostic Markers of Sepsis: Procalctionin vs C - Reactive Protein.Int.J.Curr.Res.Aca.Rev. 6(3): 12-15
doi: https://doi.org/10.20546/ijcrar.2018.603.003