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Abstract                 Volume:6  Issue-5  Year-2018          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcret@gmail.com

L-Arginine, A Nitric Oxide Donor: A Study of Its Effect on Ovarian and Endometrial Vascular Parameters and Fertility Outcome in PCO Infertile Patients
Meenal Jain*
Department of OBGYN, S.N.M.C. Agra, India
*Corresponding author
Abstract:

To study the effect of adjuvant L-arginine treatment on ovarian and endometrial vascular parameters and fertility out come in clomiphene treated PCO infertile patients. 60 PCO patients defined by revised Rotterdam criteria were randomly divided into a control and study group with 30 cases each. Control group was given clomiphene citrate (50-150 mg) for 5 days starting from the 2nd day of cycle. The study group in addition received L-arginine 3 gm per day for the whole cycle. Basal day II doppler parameters (ovarian and endometrial) were measured. They were then called for follicular monitoring starting from day 12. Doppler parameters were then evaluated and mean values calculated. Ovulatory and pregnancy rates (by earliest demonstration of fetal cardiac activity) were also noted. Cases were similar in age, BMI and duration of infertility in both groups. There was a significant improvement in vascular parameters in the study group. Uterine RI (0.489±0.284), uterine PI (2.79±0.031), PSV (14.3±1.85 cm/sec), ovarian RI (0.419±0.348), PI (1.19±0.46), PSV (15.48 cm/sec). No of mature follicles (control 0.81±0.74 and study 1.19±0.76). Endometrial thickness (control 8.1±1.21 mm and study 9.26±1.28 mm) the values were statistically significant. The PFBF was also increased (Grade-3, 4) in the study group. The ovulatory and pregnancy rate in control group was 43.3% and 13.3% respectively. While in study group the ovulatory and pregnancy rate were 66% and 30% respectively which are statistically significant. Adjuvant L-arginine treatment decreases ovarian and endometrial blood flow impedance, thus improving the vascularity which inturn increases the ovulatory and pregnancy rates in PCO infertile patients.

Keywords: Polycystic ovary,Nitric oxide donors,L-arginine,Clomiphene citrate
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How to cite this article:

Meenal Jain. 2018. L-Arginine, A Nitric Oxide Donor: A Study of Its Effect on Ovarian and Endometrial Vascular Parameters and Fertility Outcome in PCO Infertile Patients.Int.J.Curr.Res.Aca.Rev. 6(5): 7-12
doi: https://doi.org/10.20546/ijcrar.2018.605.002