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Abstract                 Volume:6  Issue-6  Year-2018          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Investigation of the Effect of Conducted Therapy on the State of the Immune System in Patients with Cutaneous Leishmaniasis
R. Raximov*
SO “Republican Specialized Scientific Practical Medical Center of Dermatovenerology and Cosmetology” of the Ministry of Health of RU, Uzbekistan
*Corresponding author
Abstract:

The study of changes in some indices of the immune system in application of a pathogenetically valid method of treatment using Mexidol and Fargals in patients with cutaneous leishmaniasis. Clinical examination was conducted in 112 patients with cutaneous leishmaniasis. Immunological methods of the research included: determination of markers of immunocompetent cells conducted by the method of indirect rosette formation, as well as determination of concentration of serum Ig classes of A, M, G were determined by the method of Mancini G. and circulating immune complexes (CIC) in blood serum – by the M Digeon method. As a result of the study, it was found that in patients with severe clinical forms of cutaneous leishmaniasis after the use of traditional therapy, the percentage of certain immunocompetent cells (CD3-, CD4-) was prone to increase (p>0.05), and with complex therapy, there was a significant increase of the relative number of CD3 cells (p<0.01) and CD4 cells (p<0.05) compared to pre-treatment data. And the relative content of CD8 cells in both treatment methods remained at the data level before the treatment (p>0.05). With regard to serum immunoglobulins, it was observed that a statistically significant decrease in the concentration of IgA and IgG (p<0.05) in relation to the data before treatment was observed in patients receiving the complex therapy, and the amount of IgM remained unchanged (p>0.05). The result of applying the complex method of treatment using Mexidol and Fargals in patients with mild clinical forms (tubercle) leishmaniasis has a positive effect by restoring the detected disorders in the immune system and regressing pathological elements on the skin. In case of severe forms (ulcerated) disease, this method of treatment of complete recovery of disorders in the immunity system does not have and this indicates the need for a repeated course of therapy in this category of patients.

Keywords: Cutaneous leishmaniasis, immunity, immunomodulators
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How to cite this article:

Raximov I. R. 2018. Investigation of the Effect of Conducted Therapy on the State of the Immune System in Patients with Cutaneous Leishmaniasis.Int.J.Curr.Res.Aca.Rev. 6(6): 65-70
doi: https://doi.org/10.20546/ijcrar.2018.606.009