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Abstract                 Volume:6  Issue-6  Year-2018          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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In- vitro Anticancer Activity of Berberine alone and in Combination with Epirubicin on Breast Cancer Cells
K.S.V. Prabhu Rathnam1,2 and C. Damodara Reddy1*
1.Sugen Life Sciences Pvt.Ltd. 4/86, S.V.Nagar Perumallapalli, Tirupathi – 517502, India
2.S.V.University, Tirupathi – 517502, India
*Corresponding author
Abstract:

Herbal medicine is a major form of treatment for more than 70% of the world's population. At present the use of patent herbal remedies comprised of dried and powdered whole herbs or herbal extracts, besides in tablet form. The study of natural products is multidisciplinary and involves several branches of biological sciences and medicine also. Natural products remain an important source of new structures, and are at the intersection of many fields. Though they may not be the final drug entity, but definitely provides a clue for the desired biological activity. Among several natural or herbal products available, Berberine, a well-known phyto compound has been chosen in the present study to decipher its mechanism of action on breast cancer alone and in combination with Epirubicin. Among the cancer types known to affect, breast cancers are common and in our country, and it’s been diagnosed in younger age patients with a poor prognosis. Thus the present study was devised to focus and tap the anti-cancer potential of Berberine alone and in combination with Epirubicin as a new therapeutic entity in the arena. The study was designed using comprehensive cellular and biochemical tools on two different human breast cancer cells namely MCF-7 & MDA MB 231 and also involved in-silico docking methods. The study results have shown great promise in terms of deciphering the mechanism of action of Berberine alone and in combination with Epirubicin on breast cancer cells. MCF-7 & MDA MB 231 cells after treatment with Berberine and Epirubicin showed features of apoptosis and also inhibited cell migration. Berberine also showed synergistic chemotherapeutic effect when used in combination with Epirubicin on MCF-7 & MDA MB 231 cells. The present study provides conclusive evidence for future pre-clinical evaluation of Berberine alone and in combination with Epirubicin befitting and upcoming breast cancer chemotherapeutic agent.

Keywords: Berberine, Breast cancer, Epirubicin, Combination therapy, Synergism.
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How to cite this article:

Prabhu Rathnam, K.S.V. and Damodara Reddy, C. 2018. In- vitro Anticancer Activity of Berberine alone and in Combination with Epirubicin on Breast Cancer Cells.Int.J.Curr.Res.Aca.Rev. 6(6): 22-42
doi: https://doi.org/10.20546/ijcrar.2018.606.004