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Abstract                 Volume:4  Issue-3  Year-2016          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Proliferatic Potential of Hematopoietic Stem Cells (HSC) and its Application in Human Diseases
Pallavi Singh1*, Naman Naik2 and Lakhan L. Naik3
1Matrikripa, G-39, Near Manju Kumari Sinha Smriti Park, P.C. Colony, Kankarbagh, Patna -800020, Bihar,  India
2Lotus 404, Welfare Diah Height, Chiragora, Dhanbad- 826001, Jharkhand, India M.Tech-Animal Biotechnology (Final Year), Sharda University, India
3Lotus 404, Welfare Diah Height, Chiragora, Dhanbad- 826001, Jharkhand, India
*Corresponding author
Abstract:

Plasticity is a newly recognized ability of stem cells to express their potential beyond the tissues from which they are derived. Organ generations have long been believed to be undertaken through organ specific and tissue specific stem cells. HSC’s(Hematopoietic Stem Cells) are involved in replenishing apoptic and damaged cells. Currently, using Cell Lineage tracking stem cells of another organ by supplementing appropriate cytokines and growth factors that provide signal for differentiating into desired organ. As suggested by McCulloch(1963), during development and proliferation of HSC interaction of C Kit (as a ligand) with its receptor on stromal cells, in bone marrow, a hierarchy of stem cells and progenitor cells differentiate and produce different sub lineage of cells. Further, most important information need to be elicited, is to decode common molecular mechanism and genes involved in initiating stem cell taking lead in differentiation to a specific organ. Neurodegenerative cells in certain neuron related diseases may be advantageously generated through this technology.

Keywords: Hematopoitic Stem Cells (HSC), Proliferatic potential, Plasticity, Progenitor cells, Cell lineage, Neurodegenerative cells.
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How to cite this article:

Pallavi Singh, Naman Naik and Lakhan L. Naik. 2016. Proliferatic Potential of Hematopoietic Stem Cells (HSC) and its Application in Human Diseases.Int.J.Curr.Res.Aca.Rev. 4(3): 86-96
doi: http://dx.doi.org/10.20546/ijcrar.2016.403.010