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Abstract                 Volume:8  Issue-5  Year-2020          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
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Review on Application and Principle of Gene Therapy in Veterinary Medicine
Wossene Negash1*, Yosef Erdachew1, Gizachew Fentahun1 and Oumer Abdulkadir1
1College of Veterinary Medicine, Samara University, P.O. Box, 132, Samara, Ethiopia
*Corresponding author
Abstract:

Gene therapy is a new modality with the potential for treating or preventing a variety of inherited or acquired diseases. For this purpose, there are a wide variety of gene delivery methods including viral and non-viral vectors. Commonly used viral methods included: retrovirus; adenovirus and lentiviral systems are suitable for gene therapeutic approaches which are based on permanent expression of the therapeutic gene. Non-viral methods included physical forces and chemical compounds to transfer DNA into a cell. Non-viral vectors are far less efficient than viral vectors, but they have advantages due to their low immunogenicity and their large capacity for therapeutic DNA. To improve the function of non-viral vectors, the addition of viral functions such as receptor mediated uptake and nuclear translocation of DNA may finally lead to the development of an artificial virus. The current literature review sets out many different models that are currently being investigated to bridge from studies in cell lines through towards clinical reality. Animal models include horse, dog, sheep, and Non-human primate models (macaque, common marmoset, owl monkey) are used for preclinical gene vector safety and efficacy trials to bridge the gap prior to clinical studies for the safety development of clinically effective delivery systems of DNA and RNA technologies. The major challenges have been delivery of DNA to the target cells and duration of expression. Ethical and moral issues implicit in gene therapy have drawn notice from several governmental and religious organizations.

Keywords: Gene therapy, Delivery systems, Non-viral vector, Viral vectors, Animal Models
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How to cite this article:

Wossene Negash, Yosef Erdachew, Gizachew Fentahun and Oumer Abdulkadir. 2020. Review on Application and Principle of Gene Therapy in Veterinary Medicine.Int.J.Curr.Res.Aca.Rev. 8(5): 23-31
doi: https://doi.org/10.20546/ijcrar.2020.805.004