Abstract            Volume:8  Issue-11  Year-2020         Original Research Articles

Online ISSN : 2347 - 3215 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcret@gmail.com

The objective of this study was to evaluate the trypanocidal effect of the aqueous extract of Ochna schweinfurthiana leavesin vitro and in vivo against two trypanosome species:Trypanosoma brucei brucei and Trypanosoma congolense. The search for chemical families by screening and evaluating the trypanocidal effects of the extract in vivo in white mice (50, 100, 200 and 400 mg / kg) and in vitro (0.25;0.5;0.75 and 1 mg/kg). Phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids and saponins. The doses of the extract of this plant resulted in a decreased motility of the two species of parasites in vitro. For the highest doses (0.5;0.75 and 1 mg/kg), the decrease is either significant (p<0.01) or highly significant (p<0.001). The activity of the extract (400 mg/kg) highly inhibited the parasite densities (p<0.001) compared to the negative control. Whereas the doses of 100 and 200 mg/kg did not significantly inhibit the parasite densities. The results recorded show an improvement in the hematocrit rate in the animals treated at different doses of the extract. This reflects a general decrease in anemia.

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