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Abstract                 Volume:8  Issue-11  Year-2020          Original Research Articles


Online ISSN : 2347 - 3215
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Invitro and Invivo Trypanocidal Effect of the Aqueous Extract of the Leaves of Ochna schweinfurthiana
Eteme Enama1*, A. N. Messi2, R. J. Mahob1, Augustin Siama3, Yede1 and A. M. Njan Nloga4
1Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Cameroon
2Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Cameroon
3Department of Parasitology and parasitic pathology, School of Veterinary Medicine and Sciences, University of Ngaoundere, Cameroon
4Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Cameroon
*Corresponding author
Abstract:

The objective of this study was to evaluate the trypanocidal effect of the aqueous extract of Ochna schweinfurthiana leavesin vitro and in vivo against two trypanosome species:Trypanosoma brucei brucei and Trypanosoma congolense. The search for chemical families by screening and evaluating the trypanocidal effects of the extract in vivo in white mice (50, 100, 200 and 400 mg / kg) and in vitro (0.25;0.5;0.75 and 1 mg/kg). Phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids and saponins. The doses of the extract of this plant resulted in a decreased motility of the two species of parasites in vitro. For the highest doses (0.5;0.75 and 1 mg/kg), the decrease is either significant (p<0.01) or highly significant (p<0.001). The activity of the extract (400 mg/kg) highly inhibited the parasite densities (p<0.001) compared to the negative control. Whereas the doses of 100 and 200 mg/kg did not significantly inhibit the parasite densities. The results recorded show an improvement in the hematocrit rate in the animals treated at different doses of the extract. This reflects a general decrease in anemia.

Keywords: Trypanosoma brucei brucei, Trypanosoma congolense,Ochna schweinfurthiana leaves, trypanocidal
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How to cite this article:

Eteme Enama, S., A. N. Messi, R. J. Mahob, Augustin Siama, Yede and Njan Nloga, A. M. 2020. In vitro and In vivo Trypanocidal Effect of the Aqueous Extract of the Leaves of Ochna schweinfurthiana.Int.J.Curr.Res.Aca.Rev. 8(11): 47-53
doi: https://doi.org/10.20546/ijcrar.2020.811.006