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Abstract                 Volume:4  Issue-3  Year-2016          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Effect of Alpha Lipoic Acid Supplementation on Nerve Conduction Velocity in Diabetic Neuropathy Patients - A Randomized Control Trial
Manish Bansal, P. K. Maheshwari, Varun Gupta* and Prabhat Agrawal
PG Department of Medicine, S N Medical College, Agra, India
*Corresponding author
Abstract:

Diabetic peripheral neuropathy (DPN) is a common, symptomatic, long-term complication of diabetes mellitus. This study was undertaken to compare the efficacy and safety of alpha-lipoic acid supplementation in diabetic neuropathy patients. This was a prospective observational study. The patients were categorized into two groups, Group I included those patients who were prescribed alpha lipoic acid while group II patients received placebo irrespective of their antidiabetic treatment. Each patient was initially accessed and followed up at 12 weeks. Demographic details, presenting symptoms, history of diabetes, laboratory values pertaining to diabetes(Fasting blood sugar, Post prandial blood sugar and HbA1c) were recorded. Nerve conduction velocity (NCV), Intensity of pain, using a visual analogue scale (VAS), diabetic neuropathy symptom (DNS) score and diabetic neuropathy examination (DNE) score, were assessed at baseline and then at 12 week follow-up. Data of 72 patients was analysed. There was statistically significant improvement in NCV, VAS, DNS and DNE score of the patients Results of this study suggest that treatment with Alpha Lipoic acid gives improvement in diabetic neuropathy. Although promising, further studies are needed to assess long-term treatment of ALA in large sample of population.

Keywords: Diabetic neuropathy, Alpha lipoic acid, NCV
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How to cite this article:

Manish Bansal, P. K. Maheshwari, Varun Gupta and Prabhat Agrawal. 2016. Effect of Alpha Lipoic Acid Supplementation on Nerve Conduction Velocity in Diabetic Neuropathy Patients – A Randomized Control Trial.Int.J.Curr.Res.Aca.Rev. 4(3): 210-219
doi: http://dx.doi.org/10.20546/ijcrar.2016.403.023