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Abstract                 Volume:4  Issue-4  Year-2016          Original Research Articles


Online ISSN : 2347 - 3215
Issues : 12 per year
Publisher : Excellent Publishers
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Hematological, Biochemical and Histopathological Changes by Bisphenol-A in Albino Pregnant Rats
Geetharathan*
Department of Biotechnology, Sri Padmavati Mahila Visvavidyalayam, Tirupati-517502, Andhra Pradesh, India
*Corresponding author
Abstract:

Bisphenol-A (BPA) is a high molecular polymer organic compound widely used all over the world. The purpose of this study was to investigate the hematological, biochemical and histological alterations in pregnant rats induced by BPA which is an estrogenic environmental contaminant.  Pregnant rats were administrated orally BPA (50 mg/kg/day.b.wt and 500mg/kg/day.b.wt). After 9 consecutive days of exposure, blood, sera and tissues were collected for hematological, biochemical and histopathological examination. Lymphocytes were separated from the spleen for rosset formation test. BPA- treated rats showed a significant reduction in red cell count, hemoglobin concentration and packed cell volume. The serum activity of alkaline phosphatase, low-density lipoprotein levels showed increased in BPA-treated groups concomitant with reduction in glucose levels. Leucogram, E-rosettes forming count and high-density lipoprotein values did not show significant differences but alter albumin & globulin levels. Histopathological alterations were detected in liver and spleen of BPA-treated rats. From the present study it could be concluded that exposure to BPA is accompanied with anemia, liver and spleen injuries in pregnant rats.

Keywords: Bisphenol-A, Pregnant rats,Spleen,Hematology,Liver Enzymes
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How to cite this article:

Geetharathan, T., 2016. Hematological, Biochemical and Histopathological Changes by Bisphenol-A in Albino Pregnant Rats.Int.J.Curr.Res.Aca.Rev. 4(4): 110-120
doi: http://dx.doi.org/10.20546/ijcrar.2016.404.013