International Journal of Current Research and Academic Review

ISSN: 2347-3215 Volume 1 Number 3 (2013) pp. 52-57

Effect of Paclitaxel along with Di allyl sulfide on Electron Transport Chain Complex changes in 7,12 Di methyl benz(a) anthracene induced skin cancer Wistar rats

N. Muninathan1 * and P.T.Komala2

Department of Biochemistry, Meenakshi Medical College and Research Instiute, Enathur, Kanchipurm, Tamil Nadu, India

A B S T R A C T

The purpose of this study is to investigate the mitochondrial electron transport chain complex and efficacy of combination of paclitaxel along with Di allyl sulfide against skin cancer in experimental animals. Skin cancer is the most common form of human cancer. The most common warning sign of skin cancer is a change in the appearance of the skin, such as a new growth or a sore that will not heal. Skin cancer is caused by chemical carcinogens and Papilloma virus infection. Skin cancer was induced in rats by 7,12 Di methyl benz(a) anthracene (DMBA) at the dosage of 5 µg was dissolved in 100µl and administered into experimental animals for 28 weeks. In this study, we demonstrated that combination of paclitaxel and Di allyl sulfide protects the rats from a lethal dose of DMBA for 30 days. The levels of electron transport chain complex of skin were found to be decreased in the cancer bearing animals when compared with control animals. Treatment of Paclitaxel along with Di allyl sulfide to cancer induced animals showed significantly increased levels of electron transport chain complex when compared with cancer induced animals. The treatment with combination of paclitaxel and Di allyl sulfide effectively increased electron transport chain complex levels. So, from the obtained results it is concluded that paclitaxel and Di allyl sulfide is capable of restoring the skin architecture.

Keywords

Mitochondrial electron transport chain complex; Skin cancer ; 7,12 Di methyl benz(a) anthracene .