International Journal of Current Research and Academic Review

ISSN: 2347-3215 Volume 1 Number 1 (2013) pp. 106-111

Cytotoxic properties of Acorus calamus in MCF -7 breast cancer cells

S.B. Sreejaya and K.S. Santhy*

Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore -641 043, Tamil Nadu, India *Corresponding author e-mail: santhyanandan@gmail.com

A B S T R A C T

In this study cytotoxic effect of Acorus calamus extract was evaluated on breast carcinoma (MCF-7) cell lines. MCF-7 cells were cultured in DMEM medium and incubated with different concentrations (18.75, 37.5, 75, 150 and 300 g/ml) of Acorus calamus methanol extract. Cell viability was assessed by MTT assay. Acorus calamus decreased cell viability in malignant cells in a concentration dependent manner. The IC50 values in MCF-7 cells were determined as 52.07 g/ml. It may be concluded that Acorus calamus can cause cell death in MCF-7 cancer cells which can be considered as a promising chemotherapeutic agent in breast cancer treatment.

Keywords

Acorus calamus; Cytotoxicity; IC50; MTT assay.